Push or Pull? Cell Proliferation and Migration During Wound Healing

Abstract

Wound healing of the skin is a complex process that is still not well-understood. Wound management is expensive for both individuals and the health system overall, and can reduce quality of life for patients. Given these significant socio-economic impacts, wound healing has long been a focus of scientific research. Recent in vivo mouse studies have identified two key regions in wounded skin tissue: A non-proliferative leading edge that actively migrates into wounded space, and a proliferative hub in which cells have enhanced mitotic properties. This work uses mathematical and computational modelling to investigate the effect of changing the mechanical characteristics of cells in these two ke..